اثر محدودیت غذایی کوتاه مدت و میانه مدت بر پاسخ انقباضی آئورت سینه‌ای موش سفید بزرگ نر

  Background & Objective : Food restriction has a protective effect against damaging agents and prevents cardiovascular disorders. This study was conducted to evaluate the effect of food restriction on contractile reactivity of male rats using isolated tissue setup.  Materials & Methods: Male Wistar rats were randomly divided into one control and three experimental groups. Control group received normal rat regimen for 6 weeks. The group with full restriction and non-isolation received 1/3 of the food regimen. The group with full restriction and isolation received 1/3 of the food regimen. The experimental group with two-week food restriction and non-isolation received 1/3 of the food regimen only for two weeks. After 6 weeks, contractile reactivity of aortic rings to KCl and noreadrenaline was determined.  Results: Although two-weeks food restriction did not produce any significant change in aortic contractile response to KCl and noreadrenaline as compared to control group, but full restriction with or without isolation increased this response relative to control group (p=0.041 and p=0.027, respectively).  Conclusion: Short-term food restriction did not have any significant effect on maximum contractile response and subchronic restriction can increase this response to KCl and noreadrenaline.